- Title
- Oxidative stress in cystic fibrosis: dietary and metabolic factors
- Creator
- Wood, Lisa G.; Fitzgerald, Dominic A.; Gibson, Peter G.; Cooper, David M.; Collins, Clare E.; Garg, Manohar L.
- Relation
- Journal of American College of Nutrition Vol. 20, Issue 2, p. 157-165
- Relation
- http://www.jacn.org/cgi/content/abstract/20/2/157
- Publisher
- American College of Nutrition
- Resource Type
- journal article
- Date
- 2001
- Description
- Objective: To examine oxidative stress in CF by measuring 8-iso-PGF2α and antioxidant defenses, in relation to dietary intake, immune function and clinical status. Methods: We measured total plasma concentrations of 8-iso-PGF2α and dietary antioxidants (vitamin E, vitamin C, ß-carotene), erythrocyte antioxidant enzyme activities (glutathione peroxidase and superoxide dismutase), lung function and dietary intake in 21 CF subjects and 21 healthy age- and gender-matched controls. Results: Total plasma 8-iso-PGF2α concentration (median [quartile 1–quartile 3]) was significantly higher in CF subjects compared to controls (214 pg/mL (155–331) vs. 135 pg/mL (101–168), p=0.001). Neutrophil, monocyte and total white cell counts were elevated in the CF group and these correlated with 8-iso-PGF2α concentration. Despite similar dietary intake, lower plasma antioxidant concentrations were observed in the CF group (vitamin E, p < 0.001, vitamin C, p=0.004, ß-carotene, p=0.001). 8-iso-PGF2α correlated negatively with plasma vitamin E, C and ß-carotene concentrations. Conclusion: Oxidative stress is increased in CF patients, despite normal dietary antioxidant intake. The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed.
- Subject
- cystic fibrosis; oxidative stress; antioxidants; isoprostanes
- Identifier
- uon:1145
- Identifier
- http://hdl.handle.net/1959.13/26808
- Identifier
- ISSN:0731-5724
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