- Title
- Regulation of RyR Channel Gating by Ca²⁺, Mg²⁺ and ATP
- Creator
- Laver, Derek R.
- Relation
- Structure and Function of Calcium Release Channels p. 69-89
- Relation
- Current Topics in Membranes 66
- Publisher Link
- http://dx.doi.org/10.1016/s1063-5823(10)66004-8
- Publisher
- Academic Press
- Resource Type
- book chapter
- Date
- 2010
- Description
- This chapter gives the current picture of how calcium release channels (ryanodine receptors, RyRs) in the sarcoplasmic reticulum (SR) are regulated by intracellular ligands. The review focuses on Ca²⁺ , Mg²⁺ , and ATP (adenosine triphosphate), which are key regulators of the RyR. DifferentRyR isoforms are expressed in skeletal and cardiac muscle. These isoforms are modulated differently by Ca²⁺ , Mg²⁺, and ATP, leading to the different characteristics of E–C coupling in the two muscle types.
- Subject
- ryanodine receptor; luminal Ca²⁺; magnesium; calcium; cardiac muscle; lipid bilayer
- Identifier
- http://hdl.handle.net/1959.13/932330
- Identifier
- uon:11317
- Identifier
- ISBN:9780123810373
- Language
- eng
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