Hyper-peptiduria in mulitple sclerosis

Title: Hyper-peptiduria in mulitple sclerosis
Creator: Jansen, D.; Brønstad, G.; Thiede, B.; Dunstan, R.; Lien, E. B.; Holmöy, T.; Reichelt, K. L.
Relation: Current Trends in Neurology Vol. 4, p. 51-60
Relation: http://www.researchtrends.net/tia/abstract.asp?in=0&vn=4&tid=47&aid=3028&pub=2010&type=3
Publisher: Research Trends
Resource Type: journal article
Date: 2010
Description: Peptides have ubiquitous regulatory roles. Preliminary investigations revealed that during the acute phase of relapse in multiple sclerosis (MS), patients had high levels of peptide like compounds in their urine and variable excretion patterns. To substantiate this finding, a larger patient cohort was studied. Urine samples from MS patients equivalent to 250 nano-moles creatinine were fractionated by HPLC (High Performance Liquid Chromatography) and C-18 reverse phase columns. The eluate was monitored at 215, 280 and 325 nanometers. Mass spectroscopy was done off line. Many were analyzed in both quiescent and active phase of their disease. Most MS patients had much higher urine peptide levels during relapse than controls, and their own peptide levels in remission.
Subject: urine peptides; multiple sclerosis; relapse
Identifier: http://hdl.handle.net/1959.13/931529
Identifier: uon:11093
Identifier: ISSN:0972-8252
Language: eng
Reviewed

		Thumbnail	File	Description	Size	Format