- Title
- Cerebellar grey matter deficits in first-episode schizophrenia mapped using cortical pattern matching
- Creator
- Rasser, Paul E.; Schall, Ulrich; Peck, Greg; Cohen, Martin; Johnston, Patrick; Khoo, Kathleen; Carr, Vaughan J.; Ward, Philip B.; Thompson, Paul M.
- Relation
- NeuroImage Vol. 53, Issue 4, p. 1175-1180
- Publisher Link
- http://dx.doi.org/10.1016/j.neuroimage.2010.07.018
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2010
- Description
- Cerebellar dysfunction has been proposed to lead to “cognitive dysmetria” in schizophrenia via the cortico-cerebellar-thalamic-cortical circuit, contributing to a range of cognitive and clinical symptoms of the disorder. Here we investigated total cerebellar grey and white matter volumes and cerebellar regional grey matter abnormalities in 13 remitted first-episode schizophrenia patients with less than 2 years’ duration of illness. Patient data were compared to 13 pair-wise age, gender, and handedness-matched healthy volunteers using cortical pattern averaging on high-resolution magnetic resonance images. Total cerebellar volume and total grey matter volumes in first-episode schizophrenia patients did not differ from healthy control subjects, but total cerebellar white matter was increased and total grey to white matter ratios were reduced in patients. Four clusters of cerebellar grey matter reduction were identified: (i) in superior vermis; (ii) in the left lobuli VI; (iii) in right-inferior lobule IX, extending into left lobule IX; and (iv) bilaterally in the areas of lobuli III, peduncle and left flocculus. Grey matter deficits were particularly prominent in right lobuli III and IX, left flocculus and bilateral pedunculi. These cerebellar areas have been implicated in attention control, emotional regulation, social functioning, initiation of smooth pursuit eye movements, eye-blink conditioning, language processing, verbal memory, executive function and the processing of spatial and emotional information. Consistent with common clinical, cognitive, and pathophysiological signs of established illness, our findings demonstrate cerebellar pathology as early as in first-episode schizophrenia.
- Subject
- psychosis; magnetic resonance imaging; cognitive dysmetria; parametric mapping; cerebellum; grey matter; white matter; cerebellar lobules; superior vermis; flocculus; pedunculus
- Identifier
- http://hdl.handle.net/1959.13/930099
- Identifier
- uon:10763
- Identifier
- ISSN:1053-8119
- Language
- eng
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