FtsK: a bacterial cell division checkpoint?

Title: FtsK: a bacterial cell division checkpoint?
Creator: Grainge, Ian
Relation: Molecular Microbiology Vol. 78, Issue 5, p. 1055-1057
Publisher Link: http://dx.doi.org/10.1111/j.1365-2958.2010.07411.x
Publisher: Wiley-Blackwell Publishing
Resource Type: journal article
Date: 2010
Description: FtsK is a multifunctional, multidomain protein that acts to co-ordinate chromosome unlinking, segregation and cell division. In this issue of Molecular Microbiology, the report by Dubarry et al. reveals new insight into the surprisingly complex relationship between the different activities of FtsK. The new study makes extensive use of fusion proteins to highlight the role of the FtsK ‘linker’ domain in helping to co-ordinate these processes. This, taken together with previous studies, suggests that FtsK is intimately involved in septum constriction, physically contacting several other divisome proteins. Further, it is attractive to speculate that FtsK can regulate the late stages of septation to act as a checkpoint to ensure DNA is fully cleared from the septum before it is allowed to close, as well as being the driving force to unlink the chromosomes and segregate the DNA away from the septum.
Subject: FtsK; chromosome unlinking; cell division; DNA; proteins
Identifier: http://hdl.handle.net/1959.13/929720
Identifier: uon:10662
Identifier: ISSN:0950-382X
Language: eng
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