- Title
- Disease Activity in Pregnant and Postpartum Women With Multiple Sclerosis Receiving Ocrelizumab or Other Disease-Modifying Therapies
- Creator
- Yeh, Wei Z.; Van Der Walt, Anneke; Ozakbas, Serkan; Buzzard, Katherine; Habek, Mario; John, Nevin A.; Prat, Alexandre; Girard, Marc; Duquette, Pierre; Baghbanian, Seyed Mohammad; Hodgkinson, Suzanne; Van Pesch, Vincent; Skibina, Olga G.; Laureys, Guy; Willekens, B; Prevost, J; Foschi, M; De Gans, K; Horakova, D; Havrdova, EK; Karabudak, R; Patti, F; Mccombe, PA; Kalincik, Tomas; Maimone, D; Altintas, A; Ampapa, R; Spitaleri, D; Gerlach, OHH; Sa, MJ; Hughes, S; Gouider, R; Mrabet, S; Macdonell, RA; Alroughani, Raed; Turkoglu, R; Cartechini, E; Al-Asmi, A; Soysal, A; Oh, J; Muros-Le Rouzic, E; Guye, S; Pasquarelli, N; Butzkueven, H; Jokubaitis, VG; Kermode, Allan G.; MSBase Study Group,; Fabis-Pedrini, Marzena J.; Carroll, William M.; Lechner-Scott, Jeannette; Boz, Cavit
- Relation
- Neurology Neuroimmunology & Neuroinflammation Vol. 11, Issue 6, no. e200328
- Publisher Link
- http://dx.doi.org/10.1212/NXI.0000000000200328
- Publisher
- Wolters Kluwer Health
- Resource Type
- journal article
- Date
- 2024
- Description
- Background and Objectives: Women with multiple sclerosis (MS) are at risk of disease reactivation in the early postpartum period. Ocrelizumab (OCR) is an anti-CD20 therapy highly effective at reducing MS disease activity. Data remain limited regarding use of disease-modifying therapies (DMTs), including OCR, and disease activity during peripregnancy periods. Methods: We performed a retrospective cohort study using data from the MSBase Registry including pregnancies conceived after December 31, 2010, from women aged 18 years and older, with relapsing-remitting MS or clinically isolated syndrome. Women were classified by preconception exposure to DMTs, including OCR, rituximab (RTX), natalizumab (NAT), stratified into active (NAT-A; continued ≥28 weeks of gestation, restarted ≤1 month postpartum) or conservative (NAT-C; continued ≤4 weeks of gestation, restarted >1 month postpartum) strategies, dimethyl fumarate (DMF) or low-efficacy DMTs (interferon-beta, glatiramer acetate). Annualized relapse rates (ARRs) were calculated for 12-month prepregnancy, pregnancy, and 6-month postpartum periods. Results: A total of 2,009 live births from 1,744 women were analyzed, including 73 live births from 69 women treated with preconception OCR. For OCR, no within-pregnancy relapse was observed and 3 women (4.1%) experienced 1 relapse in the postpartum period (ARR 0.09 [95% CI 0.02–0.27]). For NAT-A, 3 (3.7%) of 82 women relapsed during pregnancy (0.05 [0.01–0.15]) and 4 (4.9%) relapsed during postpartum (0.10 [0.03–0.26]). However, for NAT-C, 13 (15.9%) of 82 women relapsed within pregnancy (0.32 [0.20–0.51]) and 25 (30.5%) relapsed during postpartum (0.74 [0.50–1.06]). In the low-efficacy DMT group, 101 (7.6%) of 1,329 women experienced within-pregnancy relapse (0.12 [0.10–0.14]), followed by an increase in postpartum relapse activity with 234 women (17.6%) relapsing (0.43 [0.38–0.48]). This was similarly seen in the DMF group with 13 (7.9%) of 164 women experiencing within-pregnancy relapse (0.12 [0.06–0.20]) and 25 (15.2%) of 164 relapsing postpartum (0.39 [0.26–0.57]). Our RTX cohort had 0 of 24 women experiencing within-pregnancy relapse and 3 (12.5%) of 24 experiencing postpartum relapse. Discussion: Women treated with OCR or NAT-A were observed to have low relapse rates during pregnancy and postpartum. NAT-C was associated with increased risk of relapses. There was no within-pregnancy relapse in our RTX cohort, although we caution overinterpretation due to our sample size. An effective DMT strategy with a favorable safety profile for the mother and infant should be discussed and implemented well in advance of planning a family. Classification of Evidence: This study provides Class III evidence that for women with relapsing-remitting MS or clinically isolated syndrome who become pregnant, ocrelizumab, rituximab, and natalizumab (continued ≥28 weeks of gestation and restarted ≤1 month postpartum) were associated with reduced risk of relapses, compared with other therapeutic strategies.
- Subject
- multiple sclerosis (MS); Ocrelizumab (OCR); disease-modifying therapies (DMTs); women
- Identifier
- http://hdl.handle.net/1959.13/1516616
- Identifier
- uon:57002
- Identifier
- ISSN:2332-7812
- Rights
- © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
- Language
- eng
- Full Text
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