https://ogma.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:48693 Wed 29 Mar 2023 09:21:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45259 sn-glycero-2-phosphocholine and cholesterol were prepared according to the method of dried lipid film hydration. Ligands were conjugated with the surface of liposomes using optimized methods to maximize conjugation efficiency. The liposomes were characterized for particle size, ligand conjugation, drug encapsulation, liposome stability, specificity of binding, cellular internalization, mechanistic pathway of cellular uptake, and cellular toxicity. Results: Both OTR-Lipo and ATO-Lipo showed significant and specific binding to OTRs in a concentration-dependent manner compared to all control groups. There was no significant difference in binding values between OTR-Lipo and ATO-Lipo across all concentrations evaluated. In addition, OTR-Lipo (81.61%±7.84%) and ATO-Lipo (85.59%±8.28%) demonstrated significantly increased cellular internalization in comparison with rabbit IgG immunoliposomes (9.14%±1.71%) and conventional liposomes (4.09%±0.78%) at 2.02 mM phospholipid concentration. Cellular association following liposome incubation at 4.05 mM resulted in similar findings. Evaluation of the mechanistic pathway of cellular uptake indicated that they undergo internalization through both clathrin- and caveolin-mediated mechanisms. Furthermore, cellular toxicity studies have shown no significant effect of both liposomal platforms on cell viability. Conclusion: This study further supports OTRs as a novel pharmaceutical target for drug delivery. OTR-targeted liposomal platforms may provide an effective way to deliver existing therapies directly to myometrial tissue and avoid adverse effects by circumventing non-target tissues.]]> Wed 26 Oct 2022 19:46:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45243 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45239 1H nuclear magnetic resonance, dynamic light scattering (DLS), and transmission electron microscopy techniques. The CT-capped gold nanoparticles (CTAuNPs) were prepared from CT, chloroauric acid, and NaBH₄. The CTAuNPs were characterized using ultraviolet–visible, high-resolution TEM, DLS, and Fourier transform IR techniques. The cytotoxicity and apoptosis-inducing ability of both nanoparticles were determined in HepG2 cells. The results demonstrate that CTNs exhibit antiproliferative activity in the cancerous HepG2 cells. Moreover, molecular docking and molecular dynamics studies were conducted to explore the therapeutic potential of CT against human EGFR suppressor protein to gain more insights into the binding mode of the CT, which may show a significant role in anticancer therapy.]]> Wed 26 Oct 2022 15:56:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45186 Wed 26 Oct 2022 14:26:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45033 Wed 26 Oct 2022 10:59:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47692 Wed 25 Jan 2023 08:43:05 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47474 Wed 24 Jan 2024 14:18:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:16998 Wed 20 Jan 2021 17:35:44 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:37230 Wed 19 Jan 2022 15:15:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:51668 Wed 14 Feb 2024 15:32:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:44359 Wed 12 Oct 2022 08:39:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:35849 Wed 11 Dec 2019 13:27:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:15864 Wed 11 Apr 2018 18:14:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:10812 Wed 11 Apr 2018 15:38:48 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17020 Wed 11 Apr 2018 15:36:03 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:11552 Wed 11 Apr 2018 14:55:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17022 Wed 11 Apr 2018 14:23:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17010 Wed 11 Apr 2018 13:30:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17012 Wed 11 Apr 2018 12:35:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:11879 Wed 11 Apr 2018 12:33:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:3285 Wed 11 Apr 2018 12:26:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:11010 Wed 11 Apr 2018 11:06:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:11880 Wed 11 Apr 2018 09:59:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:8239 Wed 11 Apr 2018 09:46:23 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:35737 Wed 10 May 2023 13:02:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:49939 Wed 06 Mar 2024 14:38:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:50142 20 nm). The inability to precisely control nanoparticle crystallinity, size, and shape has significant implications on observed properties and therefore applications. A series of iron oxide particles have been synthesised and the impact of size as they agglomerate in aqueous media undergoing flow through a capillary tube has been studied. Reaction conditions for the production of large (side length > 40 nm) cubic magnetite (Fe3O4) have been optimised to produce particles with different diameters up to 150 nm. We have focussed on reproducibility in synthesis rather than dispersity of the size distribution. A simple oxidative cleavage of the as-synthesised particles surfactant coating transforms the hydrophobic oleic acid coated Fe3O4 to a hydrophilic system based on azelaic acid. The hydrophilic coating can be further functionalised, in this case we have used a simple biocompatible polyethylene glycol (PEG) coating. The ability of particles to either chain, flow, and fully/or partially aggregate in aqueous media has been tested in a simple in-house system made from commercial components. Fe3O4 nanoparticles (60-85 nm) with a simple PEG coating were found to freely flow at a 2 mm distance from a magnet over 3 min at a rate of 1 mL min-1. Larger particles with side lengths of ∼150 nm, or those without a PEG coating were not able to fully block the tube. Simple calculations have been performed to support these observations of magnetic agglomeration.]]> Wed 05 Jul 2023 13:08:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:30410 Wed 04 Sep 2019 09:39:34 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:37735 Tue 30 Mar 2021 09:27:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:54424 Tue 27 Feb 2024 13:57:11 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:34547 alt-naphthalene}):PC₇₁BM ([6,6]-phenyl C₇₁ butyric acid methyl ester) NP system and then compare the thermal stability of NP and BHJ films to the common poly(3-hexylthiophene) (P3HT): phenyl C₆₁ butyric acid methyl ester (PC₆₁BM) system. We find that material T_g plays a key role in the superior thermal stability of the PDPP-TNT:PC₇₁BM system; whereas for the P3HT:PC₆₁BM system, domain structure is critical.]]> Tue 26 Mar 2019 13:54:33 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:49602 Tue 23 May 2023 15:26:55 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:53305 Tue 21 Nov 2023 12:03:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:43148 Tue 13 Sep 2022 15:29:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:52383 Tue 10 Oct 2023 14:44:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:38579 in vitro lovastatin release from the alginate/chitosan/lovastatin nanoparticles under different conditions, including different alginate/chitosan ratios, different solution pH values and different lovastatin contents, were carried out by ultraviolet-visible spectroscopy. The rate of drug release from the nanoparticles is proportional to the increase in the solution pH and inversely proportional to the content of the loaded lovastatin. The drug release process is divided into two stages: a rapid stage over the first 10 hr, then the release becomes gradual and stable. The Korsmeyer-Peppas model is most suitable for the lovastatin release process from the alginate/chitosan/lovastatin nanoparticles in the first stage, and then the drug release complies with other models depending on solution pH in the slow release stage. In addition, the toxicity of alginate/chitosan/lovastatin (abbreviated ACL) nanoparticles was sufficiently low in mice in the acute toxicity test. The LD₅₀ of the drug was higher than 5000 mg/kg, while in the subchronic toxicity test with treatments of 100 mg/kg and 300 mg/kg ACL nanoparticles, there were no abnormal signs, mortality, or toxicity in general to the function or structure of the crucial organs. The results show that the ACL nanoparticles are safe in mice and that these composite nanoparticles might be useful as a new drug carrier.]]> Tue 09 Nov 2021 15:27:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:41386 Tue 02 Aug 2022 15:55:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:38899 vivo biodistribution in preclinical studies, which is important for predicting and correlating therapeutic efficacy and safety. There are a number of techniques available for analyzing the in vivo biodistribution of nanoparticles, with each having its own advantages and limitations. However, conventional techniques are limited by their inability to image the three-dimensional (3D) association of nanoparticles with cells, vasculature and other biological structures in whole organs at a subcellular level. Recently, optical clearing techniques have been used to evaluate the biodistribution of nanoparticles by 3D organ imaging. Optical clearing is a procedure that is increasingly being used to improve the imaging of biological tissues, whereby light scattering substances are removed to better match the refractive indices of different tissue layers. The use of optical clearing techniques has the potential to transform the way we evaluate the biodistribution of new and existing nanomedicines, as it allows the visualization of the interaction of nanoparticles with the biological environment in intact tissues. This review will compare the main optical clearing techniques and will address the considerations for the use of these techniques to evaluate nanoparticle biodistribution.]]> Tue 01 Mar 2022 15:48:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:37877 Thu 28 Oct 2021 13:02:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:36623 Thu 28 Oct 2021 13:02:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:34845 Thu 28 Oct 2021 12:35:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:39187 Thu 26 May 2022 09:08:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:36705 2O₂ and NH₃ precursors lead to the nucleation and growth of BN nanostructures in the presence of a boron nanoparticle. The formation of BN rings is mediated by the boron nanoparticle and is promoted by the formation of H₂O. Gas-phase H₂ is also produced during this process; however, we demonstrate that H₂ and H₂O formation serves two distinctly different roles during BN nucleation. H₂ formation promotes the clustering of B_xO_x species to form catalytic B nanoparticles; H2O formation promotes BN bond formation and ultimately BN ring condensation, both in the gas phase and at the nanoparticle surface. Thermal annealing of amorphous BN networks formed via this reaction undergo defect healing over significant simulation times (∼20 ns) to afford tube-like BN nanostructures.]]> Thu 25 Jun 2020 15:00:41 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:33591 Thu 22 Nov 2018 13:41:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:33589 Thu 22 Nov 2018 13:41:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:50339 Thu 20 Jul 2023 11:53:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:33705 x) and Nusselt number (Nu) is also investigated. Finally, the present results are compared with the previous results and the good approximation is obtained.]]> Thu 06 Dec 2018 14:18:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:7096 Sat 24 Mar 2018 10:46:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:7765 Sat 24 Mar 2018 08:41:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:7046 Sat 24 Mar 2018 08:37:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:7173 Sat 24 Mar 2018 08:34:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:1267 Sat 24 Mar 2018 08:32:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17180 Sat 24 Mar 2018 08:06:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17674 Sat 24 Mar 2018 07:57:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17883 Sat 24 Mar 2018 07:56:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:16976 Sat 24 Mar 2018 07:55:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:21317 Sat 24 Mar 2018 07:52:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:18386 Sat 24 Mar 2018 07:52:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:20033 Sat 24 Mar 2018 07:50:52 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:6767 Sat 24 Mar 2018 07:47:16 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:30122 Sat 24 Mar 2018 07:37:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:26613 nSAu) nanoparticles (n = 6, 12, 16) have been studied as the source of gold nanoparticles supported on the metal oxides NiO, TiO₂ (anatase and rutile), CeO₂, and γ-Al₂O₃ following adsorption from n-hexane and thermolysis in air at 340°C. Adsorption times increase with an increase in length of the carbon chain and vary with the metal oxide, particularly with specific surface area. Evidence of oxidation of some of the thiolate sulfur to give sulfoxide- and sulfone-type species has been established. TG/DTA studies and FT-IR (attenuated total reflectance) spectroscopy show that the adsorbed n-C_nSAu nanoparticles thermally decompose at about 210-340°C depending on the metal oxide, with some decomposition products, particularly those containing sulfur, adsorbing onto the metal oxide surface. Following thermolysis at 340°C, XPS and the FT-IR studies, combined with laser-ablation mass spectrometry, show that all organic material decomposition products are generally lost, and that the residual sulfur exists as sulfate at about 0.2 wt% or lower. TEM/STEM studies have shown that the n-C_nSAu nanoparticles, originally about 2 nm in diameter, produce gold nanoparticles with a range of 2-4 nm in size on the oxide surface following thermolysis at 340°C. The final average size of the gold nanoparticles depends on the metal oxide. For NiO, HRSTEM images shows little evidence of preferred orientation following immediate adsorption of n-C₆SAu nanoparticles, indicating weak interaction with the oxide surface, while a preferred orientation occurs on thermolysis at 340°C, indicating a much stronger interaction. The total oxidation of a representative alkane, isobutane, over TiO₂ (both anatase and rutile) and NiO, together with the addition of 5 wt% Au nanoparticles has been studied. Anatase and rutile are initially inactive but addition of the gold nanoparticles generates active oxidation catalysts, with anatase slightly more active than rutile. For NiO and 5 wt% Au/NiO reaction begins at 205-215°C and complete oxidation occurs by 430-440°C. The presence of the gold nanoparticles reduces the apparent activation energy from 89 to 51 kJ/mol. All active catalysts show formation of CO as well as CO₂ at about 20% conversion of isobutane, but at 100% oxidation the main product is almost exclusively CO₂ (>99.0%). The presence of the sulfate from the decomposition of the n-C_nS⁻ ligands has minimal apparent poisoning effect on the oxidation of isobutane for anatase, rutile, or NiO.]]> Sat 24 Mar 2018 07:34:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:27242 100 nm) of soils, but in the fine colloidal (< 100 nm) and nominally dissolved (< 1 nm) fractions of dripwaters. The concentration of Cu, Ni and Co in dripwater samples across all sites were well correlated (R2 = 0.84 and 0.70, Cu vs. Ni, Cu vs. Co, respectively), indicating a common association. Furthermore, metal ratios (Cu:Ni, Cu:Co) were consistent with NICA-Donnan n1 humic binding affinity ratios for these metals, consistent with a competitive hierarchy of binding affinity (Cu > Ni > Co) for sites in colloidal or dissolved NOM. Large shifts in Cu:Ni in dripwaters coincided with high fluxes of particulate OC (following peak infiltration) and showed increased similarity to ratios in soils, diagnostic of qualitative changes in NOM supply (i.e. fresh inputs of more aromatic/hydrophobic soil organic matter (SOM) with Cu outcompeting Ni for suitable binding sites). Results indicate that at high-flows (i.e. where fracture-fed flow dominates) particulates and colloids migrate at similar rates, whereas, in slow seepage-flow dripwaters, particulates (> 1 μm) and small colloids (1–100 nm) decouple, resulting in two distinct modes of NOM–metal transport: high-flux and low-flux. At the hyperalkaline drip site PE1 (in Poole's Cavern), high-fluxes of metals (Cu, Ni, Zn, Ti, Mn, Fe) and particulate NOM occurred in rapid, short-lived pulses following peak infiltration events, whereas low-fluxes of metals (Co and V > Cu, Ni and Ti) and fluorescent NOM (< ca. 100 nm) were offset from infiltration events, probably because small organic colloids (1–100 nm) and solutes (< 1 nm) were slower to migate through the porous matrix than particulates. These results demonstrate the widespread occurrence of both colloidal and particulate NOM–metal transport in cave dripwaters and the importance of karst hydrology in affecting the breakthrough times of different species. Constraints imposed by soil processes (colloid/particle release), direct contributions of metals and NOM from rainfall, and flow-routing (colloid/particle migration) are expected to determine the strength of correlations between NOM-transported metals in speleothems and climatic signals. Changes in trace metal ratios (e.g. Cu:Ni) in speleothems may encode information on NOM composition, potentially aiding in targeting of compound-specific investigations and for the assessment of changes in the quality of soil organic matter.]]> Sat 24 Mar 2018 07:29:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:26653 Sat 24 Mar 2018 07:26:51 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:25364 Sat 24 Mar 2018 07:24:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:4743 Sat 24 Mar 2018 07:21:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:3463 Sat 24 Mar 2018 07:20:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:23616 Sat 24 Mar 2018 07:13:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:39622 Mon 29 Jan 2024 18:49:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:44553 Mon 29 Jan 2024 17:56:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:38651 Mon 29 Jan 2024 17:49:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:42675 Mon 26 Jun 2023 15:33:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:37152 Mon 24 Aug 2020 11:10:54 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47510 Mon 23 Jan 2023 12:08:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:37526 Mon 23 Aug 2021 12:41:10 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:53254 Mon 20 Nov 2023 10:57:28 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:48490 Mon 20 Mar 2023 11:44:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47375 5 nanoparticles per cell. Despite their high concentrations, the nanoparticles were remarkably well tolerated by the cells, demonstrating their superb potential for in vivo cellular uptake. This study advances previous research on plasma-polymerized nanoparticles, introducing a low-waste synthesis method that achieves higher yields. This sustainable technology has important implications for the production of multifunctional nanoparticles for drug delivery, tumor targeting, and medical imaging.]]> Mon 19 Jun 2023 14:59:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:43031 Mon 12 Sep 2022 11:35:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:49262 Mon 08 May 2023 11:02:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47748 in vivo in a murine model of preterm labour. The aim of this study was to report the pharmaceutical synthesis and characterization of the OTR-PEG-ILs and investigate their specific cellular interaction with OTR-expressing myometrial cells in vitro. Immunoliposomes composed of 1,2-distearoyl-sn-glycero-2-phosphocholine (DSPC) and cholesterol were prepared using an optimized method for the coupling of low concentrations of antibody to liposomes. The liposomes were characterized for particle size, antibody conjugation, drug encapsulation, liposome stability, specificity of binding, cellular internalization, mechanistic pathway of cellular uptake, and cellular toxicity. Cellular association studies demonstrated specific binding of OTR-PEG-ILs to OTRs and significant cellular uptake following binding. Evaluation of the mechanistic pathway of cellular uptake indicated that they undergo internalization through both clathrin- and caveolin-mediated mechanisms. Furthermore, cellular toxicity studies have shown no significant effect of OTR-PEG-ILs or the endocytotic inhibitors on cell viability. This study further supports oxytocin receptors as a novel pharmaceutical target for drug delivery to the uterus.]]> Fri 27 Jan 2023 09:49:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:51911 Fri 22 Sep 2023 10:39:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:52664 Fri 20 Oct 2023 09:09:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:35933 alt-5,10-bis((2-hexyldecyl)oxy)dithieno[3,2-c:3',2'-h][1,5]naphthyridine-2,7-diyl] (PTNT) and fullerene blend utilizing chloroform as well as a non-chlorinated and environmentally benign solvent, o-xylene, as the miniemulsion dispersed phase solvent. The nanoparticles (NPs) in the solid-state film were found to coalesce and offered a smooth surface topography upon thermal annealing. Organic photovoltaics (OPVs) with photoactive layer processed from the nanoparticle dispersions prepared using chloroform as the miniemulsion dispersed phase solvent were found to have a power conversion efficiency (PCE) of 1.04%, which increased to 1.65% for devices utilizing NPs prepared from o-xylene. Physical, thermal and optical properties of NPs prepared using both chloroform and o-xylene were systematically studied using dynamic mechanical thermal analysis (DMTA) and photoluminescence (PL) spectroscopy and correlated to their photovoltaic properties. The PL results indicate different morphology of NPs in the solid state were achieved by varying miniemulsion dispersed phase solvent.]]> Fri 19 Jun 2020 12:14:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:42295 Fri 19 Aug 2022 14:58:40 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:53052 Fri 17 Nov 2023 11:54:49 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47347 Fri 13 Jan 2023 12:30:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:47339 Fri 13 Jan 2023 12:16:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:38589 Fri 12 Nov 2021 15:59:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:49367 Fri 12 May 2023 12:42:06 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:41780 Fri 12 Aug 2022 12:03:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:46128 Fri 11 Nov 2022 15:22:03 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:51550 Fri 08 Sep 2023 15:06:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:12404 Fri 07 Dec 2018 15:50:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45590 Fri 04 Nov 2022 10:42:47 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:45706 Fri 04 Nov 2022 08:55:56 AEDT ]]>