https://ogma.newcastle.edu.au/vital/access/manager/Index ${session.getAttribute("locale")} 5 Injury leads to the appearance of cells with characteristics of both microglia and astrocytes in mouse and human brain https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:33579 Wed 19 Jan 2022 15:18:17 AEDT ]]> The venous manifestations of pulse wave encephalopathy: windkessel dysfunction in normal aging and senile dementia https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:4329 Wed 11 Apr 2018 16:27:34 AEST ]]> Alzheimer's disease patient groups derived from a multivariate analysis of cognitive test outcomes in the coalition against major diseases dataset https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:25160 Wed 11 Apr 2018 16:09:03 AEST ]]> Unveiling clusters of RNA transcript pairs associated with markers of Alzheimer's disease progression https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:15137 Wed 11 Apr 2018 14:14:06 AEST ]]> Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:16003 Wed 11 Apr 2018 12:17:35 AEST ]]> Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:9495 Wed 11 Apr 2018 10:57:13 AEST ]]> Use of pattern classification to identify mild cognitive impairment and predict cognitive decline https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:10767 Wed 11 Apr 2018 10:09:10 AEST ]]> Astrocytes: a central element in neurological diseases https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:27925 Wed 10 Nov 2021 15:05:24 AEDT ]]> The influence of Schisandrin B on a model of Alzheimer's disease using ß-amyloid protein Aß₁₋₄₂-mediated damage in SH-SY5Y neuronal cell line and underlying mechanisms https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:32468 1-42). In particular, the purpose of this investigation was to examine alterations in mRNA and protein expression of DNMT. Data demonstrated that schisandrin B blocked Aß1-42-mediated injury in SH-SY5Y neuronal cell line as evidenced by a restoration of cellular morphology and cell viability to approximate control levels at the highest 10 µg/ml Schisandrin B. Incubation with Aß1-42 significantly decreased mRNA and protein expression of DNMT3A and DNMT1 in SH-SY5Y neuronal cell line. Incubation with Aß1-42 followed by 24 treatment with schisandrin B significantly inhibited the Aß1-42 -induced changes in mRNA and protein expression of DNMT3A and DNMT3B in a concentration-dependent manner. It is of interest that the mRNA expression of DNMT3A and DNMT1 were significantly higher than control. Data thus indicate schisandrin B was effective in inhibiting the actions of Aß1-42 on cell survival and morphology and that DNA methylation may be associated with the beneficial findings.]]> Wed 06 Jun 2018 14:05:00 AEST ]]> Recent progress in translational research on neurovascular and neurodegenerative disorders https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:34333 Wed 02 Mar 2022 14:24:45 AEDT ]]> Therapeutic potential of mitophagy-inducing microflora metabolite, urolithin a for alzheimer’s disease https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:53452 Tue 28 Nov 2023 10:10:49 AEDT ]]> Automatic Alzheimer's disease recognition from MRI data using deep learning method https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:30576 Tue 02 Apr 2019 10:09:28 AEDT ]]> Odor Identification Impairment and Change with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:39950 Thu 30 Jun 2022 14:36:45 AEST ]]> A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA) https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:40278 Thu 28 Jul 2022 13:54:47 AEST ]]> Elevated plasma ferritin in elderly individuals with high neocortical amyloid-β load https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:36161 Thu 20 Feb 2020 14:45:19 AEDT ]]> Reducing falls among people living with dementia: A systematic review https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:48130 Thu 02 Mar 2023 15:41:31 AEDT ]]> In vivo mapping of incremental cortical atrophy from incipient to overt Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:8429 Sat 24 Mar 2018 08:40:48 AEDT ]]> Dementia: 14 Essentials of management https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:18300 Sat 24 Mar 2018 08:04:26 AEDT ]]> Memory impairment is associated with serum methylarginines in older adults https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:17876 Sat 24 Mar 2018 07:56:43 AEDT ]]> Increased cerebrospinal fluid level of insulin-like growth factor-II in male patients with Alzheimer's disease https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:26280 Sat 24 Mar 2018 07:40:12 AEDT ]]> Impact of Alzheimer's disease in nine Asian countries https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:25960 Sat 24 Mar 2018 07:36:58 AEDT ]]> Plasma protein profiling of mild cognitive impairment and Alzheimer's disease across two independent cohorts https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:28945 Sat 24 Mar 2018 07:31:25 AEDT ]]> Effects of testosterone on synaptic plasticity mediated by androgen receptors in male SAMP8 mice https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:25302 Sat 24 Mar 2018 07:30:19 AEDT ]]> Screening for dementia in primary care: a comparison of the GPCOG and the MMSE https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:26028 Sat 24 Mar 2018 07:26:29 AEDT ]]> Hierarchical ensemble learning for Alzheimer's disease classification https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:35263 Mon 08 Jul 2019 16:52:24 AEST ]]> The effects of phenylethanoid glycosides, derived from Herba cistanche, on cognitive deficits and antioxidant activities in male SAMP8 mice https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:34031 Herba cistanche, are known to exert protective effects on cognitive deficits in Alzheimer's disease (AD); however, the underlying mechanisms of this herbal extract on cognitive performance remain unclear. The aim of this study was thus to examine the protective mechanism attributed to PhG on cognitive deficits in an AD senescence accelerated mouse prone 8 (SAMP8) model. Cognitive deficit parameters examined included (1) Morris water maze (MWM) assessing cognitive performance and (2) quantification of dendritic spine density in hippocampal CA1 region by Golgi staining, a molecular biomarker of synaptic function. In addition, levels of malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and gluthathione peroxidase (GSH-Px) were determined to examine the potential role of oxidant processes in cognitive dysfunction. Data showed that PhG significantly decreased escape latency and path length, associated with a rise in the percentage of time spent in the target quadrant and number of platform crossings. In addition, PhG significantly increased dendritic spine density in the hippocampal CA1 region accompanied by elevated expression levels of synaptophysin (SYN) and post synaptic density 95 (PSD-95), reduced MDA content, and elevated the activities of SOD and GSH-Px. Data suggest that the ability of PhG to ameliorate cognitive deficits in SAMP8 mice may be related to promotion in synaptic plasticity involving antioxidant processes.]]> Mon 04 Feb 2019 11:38:53 AEDT ]]> Regional changes with global brain hypometabolism indicates a physiological triage phenomenon and can explain shared pathophysiological events in Alzheimer’s & small vessel diseases and delirium https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:50078 Fri 30 Jun 2023 15:18:13 AEST ]]> Proto-animate²⁰ https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:10324 Fri 13 Sep 2024 11:10:23 AEST ]]> A Synergistic Combination of DHA, Luteolin, and Urolithin A Against Alzheimer’s Disease https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:52486 Fri 13 Oct 2023 10:03:34 AEDT ]]> Change in odor identification impairment is associated with improvement with cholinesterase inhibitor treatment in mild cognitive impairment https://ogma.newcastle.edu.au/vital/access/manager/Repository/uon:33774 Fri 11 Jan 2019 14:26:39 AEDT ]]>