Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/925087
- Folate nutritional genetics and risk for hypertension in an elderly population sample
- The University of Newcastle. Faculty of Science & Information Technology, School of Environmental and Life Sciences
- Background/Aims: 118 elderly participants (65–90 years) were assessed for any relationship between folate, related genes and hypertension. Methods: Six B-vitamin-related SNPs were genotyped in 80 normotensive and 38 hypertensive subjects. Results: Of six polymorphisms (677C>T-MTHFR, 1298A>C-MTHFR, 80G>A-RFC, 2756A>G-MS, 66A>G- MSR, 19bpDHFR and 1561C>T-GCPII), only 677C>T-MTHFR was a significant risk for hypertension: OR 1.89; 95% CI 1.07–3.32 (χ² p = 0.038). Additionally, hypertensive subjects had a significantly lower intake of dietary folate than normotensive individuals (p = 0.0221), although this did not markedly alter blood metabolite levels. Several significant linear associations between dietary folate and related blood metabolites were found in normotensive subjects (p<0.001 for Hcy, red cell and serum folate) and were as predicted on an a priori basis – generally weaker associations existed in hypertensive subjects (p<0.05 for serum folate). This was true for data examined collectively or by genotype. Multiple regression analysis for diastolic or systolic blood pressure showed significant interaction for gender and folate intake (p = 0.014 and 0.019, respectively). In both cases this interaction occurred only in females, with higher folate intake associated with decreased blood pressure. Regressing diastolic blood pressure and 677C>T-MTHFR genotype showed significance (males; p = 0.032) and borderline significance (all subjects). Conclusion: Dietary folate and 677C>T-MTHFR genotype may modify blood pressure.
- Journal of Nutrigenetics and Nutrigenomics Vol. 2, Issue 1, p. 1-8
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