Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/43339

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Title
Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency
Author/Creator
Westcott, Kerryn T.;  Hirst, Jonathan J.;  Ciurej, Isabella;  Walker, David W.;  Wlodek, Mary E.
Institution
The University of Newcastle. Faculty of Health, School of Biomedical Sciences and Pharmacy
Description
Background/Aims: Allopregnanolone suppresses central nervous system activity and has neuroprotective actions in hypoxia-induced brain injury. In pregnant sheep allopregnanolone concentrations are high during fetal life and decline rapidly after birth. We investigated brain allopregnanolone concentrations of fetal and postnatal rats derived from normal and growth restricted pregnancies. Methods: Bilateral uterine vessel ligation (or sham) was performed at gestation day 18 to induce uteroplacental insufficiency in WKY rats (n = 7-8 per group). Brain allopregnanolone was measured by radioimmunoassay at 2 study ages, gestation day 20 (n = 6 per group) and postnatal day 6 (n = 6-8 per group), from control and growth-restricted pups. Results: Fetal brain allopregnanolone concentrations were higher in growth-restricted fetuses compared to control (p<0.05). Allopregnanolone concentrations decreased at birth with a greater decline in growth restriction (p<0.05). Postnatal day 6 brain allopregnanolone concentrations were lower in growth restriction (p<0.05). Conclusions: Growth restriction is a potent stimulus for neurosteroid synthesis in the fetal brain in late pregnancy. The low concentrations of allopregnanolone in the growth-restricted postnatal brain suggest a delay in the capacity of the adrenal gland or brain to synthesize pregnane steroids or their precursors and may render the postnatal brain vulnerable to hypoxia-induced injury.
Relation
Neuroendocrinology Vol. 88, Issue 4, p. 287-292
Publisher Link
http://dx.doi.org/10.1159/000139771
Date
2008
Publisher
Karger
Keyword(s)
brain;  allopregnanolone;  uteroplacental insufficiency;  growth restriction
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/43339
Identifier
ISSN:0028-3835
Reviewed
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Subject
"Neuroendocrinology"
 
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