This cross-sectional study describes oxidative stress and antioxidant status in 54 pediatric oncology patients undergoing chemotherapy. Plasma 8-iso-prostaglandin-F2α(8-iso-PGF2α), vitamins A and E and β-carotene, and erythrocyte activities of superoxide dismutase and glutathione peroxidase levels were assessed. One-third of the patients (34%) had plasma 8-iso-PGF2α levels higher than the upper limit of the normal range (> 40 ng/mL). The majority (> 80%) had plasma levels of vitamins A and E and β-carotene within the normal range. Superoxide dismutase activity was lower than the reference range (< 2.4 U/mg Hb) in all patients, whereas erythrocyte glutathione peroxidase activity was lower than the reference range in 46%. Advanced-stage cancer was associated with increased lipid peroxidation but treatment-related factors or use of dietary supplements was not, suggesting that the oxidant-antioxidant balance may be disturbed in a large proportion of this group. Prospective studies would establish whether antioxidant supplementation plays a role in clinical treatment for pediatric oncology patients.
Journal of Cancer Integrative Medicine Vol. 3, Issue 2, p. 41-50