Please use this identifier to cite or link to this item: http://hdl.handle.net/1959.13/936912

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Title
Effectiveness of H1N1/09 monovalent and trivalent influenza vaccines against hospitalization with laboratory-confirmed H1N1/09 influenza in Australia: a test-negative case control study
Author/Creator
Cheng, Allen C.;  Kotsimbos, Tom;  Wood-Baker, Richard;  Senanayake, Sanjaya N.;  Brady, Stephen J.;  Paterson, David L.;  Wark, Peter A.;  Upham, John W.;  Korman, Tony M.;  Dwyer, Dominic E.;  Waterer, Grant W.;  Kelly, Paul M.;  Kelly, Heath A.;  Irving, Louis B.;  Bowler, Simon D.;  Brown, Simon G. A.;  Holmes, Mark;  Jenkins, Christine R.;  Thompson, Philip;  Simpson, Graham
Institution
The University of Newcastle. Faculty of Health, School of Medicine and Public Health
Description
We aimed to estimate the effectiveness of H1N1/09 containing influenza vaccines against hospitalization from influenza in Australia. We performed a test-negative case control study in patients hospitalized in 15 sentinel Australian hospitals between March and November 2010, comparing influenza vaccination (H1N1/09 monovalent or 2010 seasonal trivalent) in hospitalized patients with PCR-confirmed influenza compared to PCR-negative controls. Between March and November 2010, 1169 hospitalized patients were tested for suspected influenza, of which influenza vaccine status was ascertained in 165/238 patients with H1N1/09 influenza, 40/64 with seasonal influenza and 558/867 test negative controls; 24% of H1N1/09 cases, 43% of seasonal influenza cases and 54% of controls were vaccinated. VE against hospitalisation with H1N1/09 influenza after adjusting for age, medical comorbidities and pregnancy status was estimated at 49% (95% CI: 13%, 70%). Influenza vaccination was associated with a reduction in hospitalisation caused by H1N1/09 influenza in the 2010 southern hemisphere winter season.
Relation
Vaccine Vol. 29, Issue 43, p. 7320-7325
Publisher Link
http://dx.doi.org/10.1016/j.vaccine.2011.07.087
Date
2011
Publisher
Elsevier
Keyword(s)
influenza complications;  case control studies;  influenza vaccines
Resource Type
journal article
Identifier
http://hdl.handle.net/1959.13/936912
Identifier
ISSN:0264-410X
Reviewed
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Subject
"Vaccine"
 
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